![]() Pcl was originally identified in Drosophila melanogaster as a gene required for the development of body segments in the fly. Citation 2-5 Impaired PRC2 activity is associated with defects in cell differentiation and growth and can lead to cellular transformation. Citation 1 The PRC2 complex methylates lysine 27 of histone H3, producing mono-, di- and tri-methylated H3K27me1/2/3 marks that generally correlate with transcriptionally repressed chromatin. ![]() Polycomblike (Pcl) proteins are essential components of the Polycomb Repressive Complex 2 (PRC2) that silences genes during development and lineage specification.
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